The Powerpuff Girls are the Radioactive Uber Clan's Peace negotiators of peace. Their job is to peacefully stop any potential fights or to break up any arguments before they become worse.
When Popeye The Sailor, Ruben's Nuts, Count Chocula, Jafar, Fat Albert, and Plink Panther were out to scout an abandoned city destroyed by demons, they heard three cries. The team went to the area and saw three girls crying over their dead fathers body: Bubbles, Blossom, and Buttercup. They said that a giant red demon blob came out of nowhere and ate their fathers brain while they watched. Turns out that the giant red blob who destroyed the entire city was SpotxSpott who merged with Bern to terrorize the city with their merged powers.
This was when Detective Strawberry came in and tried to arrest the RUC for being vigilantes. However the girls showed their biggest strength to everyone: Their peace negotiation. They peacefully gave peace and convinced Detective Strawberry to back down and look for any survivors of this horrible accident. Strawberry ran off to look for any survivors.
Popeye adopted the three girls as his adopted, role model children. Every day he would brush their teeth and hair, read them bedtime stories, feed them, and train them to be peace negotiators. Later on RUC member Peter Griffin admitted he might have developed a small crush on Bubbles due to how kind she is.
They are considered to be the best at what they do and they love to give peace as best as they possibly can. They do not like violence whatsoever but will create small traps to slow down or stop any demons or criminals when necessary.